The aesthetic industry in 2026 is defined by a major shift toward cellular repair. While dermal fillers remain a cornerstone for volume, Polynucleotides (PN) have emerged as the premier solution for skin quality. These are not fillers; they are DNA-based molecules designed for deep tissue regeneration. For European clinics, securing a reliable supply of these regenerative biostimulators has become a strategic priority in clinical procurement.
The Science of DNA Repair: PN-HPT® and PDRN
Polynucleotides are long chains of nucleotides derived from salmon DNA, purified to be highly biocompatible. Unlike hyaluronic acid, which provides passive hydration, PN molecules are metabolically active. They interact with A2A receptors to stimulate fibroblasts, increase collagen type I production, and promote angiogenesis for better skin oxygenation.
Plinest by Mastelli: The Italian Innovation
Plinest is the pioneer of the PN movement, utilizing the patented PN-HPT® (High Purification Technology). This specialized process ensures a product of the highest safety and purity for medical use.
- Primary Action: It works directly on the dermal matrix to reverse photo-aging and treat elastosis.
- Clinical Application: Ideal for the face, neck, and décolletage to restore firmness and elasticity.
- The Synergistic Result: By reinforcing the "biological soil" of the skin, Plinest creates a foundation where fillers or lasers perform with significantly greater efficiency.
Rejuran I: The Periorbital Specialist
While the Mastelli range offers broad structural support, the Korean-made Rejuran range focuses on intensive healing. Rejuran I (the "I" standing for Eye) is a lower-viscosity formulation specifically engineered for the delicate periorbital area.
Its specificity lies in its ability to thicken the dermis without the risks associated with traditional fillers. Practitioners choose Rejuran I because it avoids the Tyndall effect (bluish tint) and prevents the chronic edema often seen with hyaluronic acid in the tear trough. It focuses on improving the skin's internal structure to naturally mask dark circles and fine lines.
Regenerative Stacking: The 2026 Protocol
The current medical consensus involves combining Polynucleotides with classic cross-linked fillers. This "Regenerative Stacking" is now a baseline for advanced clinics: the PN repairs the cellular environment, while the filler provides immediate structural support.
RM365 Netherlands provides the original PN range from Mastelli and Rejuran with VAT-free shipping for EU practitioners, ensuring your clinic stays at the forefront of regenerative medicine.
The information below is required for social login
Sign In
Create New Account